Hereditary Gastrointestinal Polyposis Syndromes: A Review Including Newly Identified Syndromes

There are multiple hereditary and non-hereditary polyposis syndromes that were originally categorized as adenomatous or hamartomatous. More recently, serrated polyps and their syndromes have been defined. Nearly all of these syndromes have a risk of colorectal cancer in the individuals and affected family members. Most of these syndromes are associated with extracolonic manifestations, including extracolonic tumors. The major clinical features, genetic mechanisms, and clinical management of Familial Adenomatous Polyposis (FAP), Peutz-Jeghers Syndrome (PJS), Juvenile Polyposis Syndrome (JPS), PTEN Hamartoma Syndrome (PTHS), and the more recently described syndromes MUTYH-Associated Polyposis, Hereditary Mixed Polyposis Syndrome, Serrated Polyposis Syndrome, and Polymerase Proofreading Associated Polyposis are summarized in this article. *Corresponding author: Aaron Ryan Huber, University of Rochester Medical Center, Surgical Pathology Unit, 601 Elmwood Avenue, Rochester, NY 14618, USA, Tel: (585) 275-1702; FAX: (585) 276-2802; E-mail: [email protected] Received November 06, 2013; Accepted November 21, 2013; Published November 29, 2013 Citation: Huber AR, Findeis-Hosey JJ, Whitney-Miller CL (2013) Hereditary Gastrointestinal Polyposis Syndromes: A Review Including Newly Identified Syndromes J Gastroint Dig Syst 3: 155. doi: 10.4172/2161-069X.1000155 Copyright: © 2013 Huber AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.